Substitution at R3 which has a halogen or alkoxy group (74f–74i) led to a slight rise in mobile potency with the halide analogs (74g–h) showing greatest the potency within the group. Further optimization triggered the discovery of 74i–j, with 74k as by far the most Lively compound within the collection https://buyindazole86430.timeblog.net/67318515/the-indazole-nmr-diaries