Succinic semialdehyde dehydrogenase deficiency is often a disease that triggers GHB to build up from the blood. GHB is equally a precursor and metabolite with the neurotransmitter GABA which is existing in the brain in μM concentrations. GHB binds to at least two distinct populations of small- and large-affinity binding https://colettem383uky5.thebindingwiki.com/user