Chemotherapy was potentiated by E7449 and single agent had important antitumor exercise in BRCA-deficient xenografts. Additionally, E7449 inhibited Wnt/β-catenin signaling in colon cancer cell traces, possible through TNKS inhibition. In step with this probability, E7449 stabilized axin and TNKS proteins causing β-catenin de-stabilization and significantly altered expression of Wnt ta... https://jacquesi197vae9.wikiadvocate.com/user