Conolidine’s analgesic results stem from its conversation with non-opioid pain pathways. In contrast to opioids, which bind to µ-opioid receptors within the central anxious process, conolidine modulates alternate molecular targets. A Science Improvements examine found that conolidine interacts with the atypical chemokine receptor ACKR3/CXCR7, which regulates opioid peptide availability. https://mylesppznn.myparisblog.com/38165924/a-review-of-alternative-natural-pain-relief-to-replace-traditional-painkillers